Thermo Fisher Scientific SETD8 Monoclonal Antibody (OTI5C7), TrueMAB
인간 SETD8 단백질을 인식하는 단클론 항체로 Western blot에 최적화되어 있습니다. 무보존제, 동결건조 형태이며 재구성 후 1 mg/mL 농도로 사용 가능합니다. 세포 증식 및 염색질 구조 연구에 활용됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C7 |
| Immunogen | Full length human recombinant protein of human SETD8 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
SETD8 is a histone methyltransferase that specifically monomethylates Lys-20 of histone H4.
This modification is enriched during mitosis and serves as a marker for epigenetic transcriptional repression.
SETD8 functions mainly in euchromatin regions, playing a central role in silencing euchromatic genes, supporting cell proliferation, chromosome condensation, and cytokinesis.
Nucleosomes are preferred substrates compared to free histones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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