Thermo Fisher Scientific 5HT2C R Polyclonal Antibody
Rabbit polyclonal antibody targeting human 5HT2C receptor. Validated for WB and IHC applications. Lyophilized form with no preservative, suitable for research use. Stable at -20°C with optional glycerol addition for long-term storage.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 400–450 of human 5HT2C receptor conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: 5HT2C receptor.
Target Information
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways.
This gene encodes the 2C subtype of serotonin receptor and its mRNA undergoes multiple RNA editing events, converting adenosine residues to inosines. These edits alter amino acids within the second intracellular loop of the receptor, generating isoforms that differ in G protein interaction and activation of phospholipase C and D signaling cascades. This modulates serotonergic neurotransmission in the central nervous system. Abnormal patterns of 5-HT2C editing have been reported in depressed suicide victims.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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