Thermo Fisher Scientific SOS1 Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 SOS1 단백질에 대한 Rabbit Polyclonal Antibody. Western blot에 사용 가능하며, Affinity chromatography로 정제됨. 액상 형태로 제공되며, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SOS1 (Accession Q07889), corresponding to amino acid residues L1056–D1106 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853855 |
Product Specific Information
Antibody detects endogenous levels of total SOS1.
Target Information
Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1 and its closely related Sos2 paralog contain:
- N-terminal histone-binding domain
- RacGEF catalytic (DH) domain with a PH domain
- Ras exchanger motif (REM) domain
- RasGEF catalytic domain
- C-terminal proline-rich region
Sos1 catalyzes the GDP–GTP exchange within the membrane-bound GTPase Ras, activating the MAPK cascade critical for cellular proliferation, survival, and differentiation. Growth factor stimulation induces phosphorylation of Sos on multiple serine and threonine residues, and phosphorylation within the C-terminus by MAP/ERK kinase disrupts the Grb2–Sos complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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