Thermo Fisher Scientific LRP2 Polyclonal Antibody
Thermo Fisher Scientific의 LRP2 Polyclonal Antibody는 Mouse 및 Rat 시료에 반응하는 Rabbit IgG 항체로, WB, IHC, ICC, ELISA 등에 사용 가능. 고순도 친화 크로마토그래피 정제, 안정적 액상 형태로 -20°C 보관. 세포막 단일 통과형 단백질 LRP2 검출에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 4446–4655 of human LRP2 (NP_0045162) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.35 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300, 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806358 |
Product Specific Information
- Immunogen sequence:
FHYRRTGSLL PALPKLPSLS SLVKPSENGN GVTFRSGADL NMDIGVSGFG PETAIDRSMA MSEDFVMEMG KQPIIFENPM YSARDSAVKV VQPIQVTVSE NVDNKNYGSP INPSEIVPET NPTSPAADGT QVTKWNLFKR KSKQTTNFEN PIYAQMENEQ KESVAATPPP SPSLPAKPKP PSRRDPTPTY SATEDTFKDT ANLVKEDSEV - Positive Samples: Mouse lung
- Cellular Location: Membrane, Single-pass type I membrane protein, coated pit
Target Information
Low density lipoprotein-related protein 2 (LRP2), also known as megalin, is a multi-ligand endocytic receptor expressed mainly in absorptive epithelial tissues such as the kidney. It possesses a large extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. LRP2 binds various macromolecules, including albumin, apolipoproteins B and E, and lipoprotein lipase, and is essential for reuptake of ligands like lipoproteins, sterols, vitamin-binding proteins, and hormones.
It also plays a role in cell signaling, interacting with parathyroid hormones and sonic hedgehog extracellularly, and MAP kinase scaffold proteins and JNK interacting proteins intracellularly. Recycling of LRP2 is regulated by phosphorylation of its cytoplasmic domain.
Mutations in LRP2 cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-92032_LRP2_P98164-1_Rabbit.svg)
(이미지: PA5-92032_LRP2_P98164-1_Rabbit_PDP.jpeg)
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