Thermo Fisher Scientific MIA Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 5–15 µg/mL

Product Specifications

Product Specific Information

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

Tumorigenesis is a process mediated by a network of membrane, cytosolic, and nuclear-associated factors regulating proliferation and cell-matrix interactions through signaling cascades. The phenotype of malignant melanomas depends on the balance of stimulatory or inhibitory factors generated by both tumor cells and their environment.
Melanoma inhibitory activity (MIA), also known as cartilage-derived retinoic acid-sensitive protein (CD-RAP), is a Src homology 3 (SH3)-like domain-containing protein secreted from chondrocytes and malignant melanoma cells. MIA is synthesized as a 131-amino acid pro-form and processed into a mature 107-amino acid protein after signal peptide cleavage. It is expressed during chondrogenesis and in mature chondrocytes, indicating its role in maintaining normal cartilage cell phenotype. MIA mRNA is also detected in carcinomas of the colon, ovary, kidney, and head/neck, suggesting its potential as a marker for monitoring melanomic activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.