Thermo Fisher Scientific MLK1 Polyclonal Antibody
MLK1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P) 분석에 적합합니다. Human 및 Mouse 시료에 반응하며, MAP3K9 유래 펩타이드를 면역원으로 사용했습니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP3K9 (Accession P80192), corresponding to amino acid residues D1005–F1055. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852654 |
Product Specific Information
Antibody detects endogenous levels of total MAP3K9.
Target Information
MAP3K9 (MLK1) is a serine/threonine protein kinase that functions in the MAP kinase pathway. It plays an important role in cellular response cascades triggered by environmental changes. Once activated, it acts as an upstream activator of the MKK/JNK signal transduction cascade through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, which in turn activate JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. MAP3K9 also participates in the mitochondrial death signaling pathway, including cytochrome c release leading to apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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