Thermo Fisher Scientific SUPT4H1 Polyclonal Antibody
SUPT4H1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P)에서 검증됨. Human 및 Mouse 반응성. 액상 형태, 1 mg/mL 농도, PBS/glycerol buffer에 보관. mRNA 전사 조절 연구용으로 적합.
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- PA5103308
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Thermo Fisher Scientific SUPT4H1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SUPT4H1 (Accession P63272), corresponding to amino acid residues N79–T117. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852653 |
Product Specific Information
Antibody detects endogenous levels of total SUPT4H1.
Target Information
SUPT4H1 is a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II.
DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. It cooperates with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing near promoter sites, facilitating assembly of elongation-competent RNA polymerase II complexes.
DSIF and NELF promote pausing by inhibiting transcription elongation factor TFIIS/S-II. TFIIS/S-II binds RNA polymerase II at pause sites and stimulates transcript cleavage, enabling resumption of transcription.
DSIF also positively regulates elongation and is required for efficient activation by HIV-1 Tat, suppressing pausing and preventing premature transcript release from HIV-1 LTR regions.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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