Thermo Fisher Scientific MYC Epitope Tag Polyclonal Antibody

Thermo Fisher Scientific MYC Epitope Tag Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge if not clear after standing at room temperature.
• Stable for several weeks at 4°C as undiluted liquid.
• Dilute only before immediate use.

This affinity-purified antibody is directed against human c-Myc and detects overexpressed proteins containing the Myc epitope tag. It recognizes the Myc-tag (Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu) fused to either the amino- or carboxy-termini of targeted proteins in transfected or transformed cells.

Target Information

Myc is a proto-oncogene encoding a nuclear phosphoprotein involved in cell cycle progression, apoptosis, and cellular transformation. The protein forms a heterodimer with MAX, binding to the E-box DNA consensus sequence to regulate gene transcription. Gene amplification is common in various human cancers. Translocations involving Myc are associated with Burkitt lymphoma and multiple myeloma. Translation may initiate from both upstream non-AUG (CUG) and downstream AUG start sites, producing two isoforms with distinct N-termini.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.