Thermo Fisher Scientific RFXANK Polyclonal Antibody
RFXANK 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼에 보관. 인간 시료에 반응하며 연구용으로 적합.
- 카탈로그번호
- PA561899
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RFXANK. Recombinant protein control fragment (Product # RP-101105) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646499 |
Product Specific Information
Immunogen sequence:
TQPAEDLIQT QQTPASELGD PEDPGEEAAD GSDTVVLSLF PCTPEPVNPE PDASVSSPQ
Sequence identity to orthologs:
- Mouse: 63%
- Rat: 66%
Target Information
Major histocompatibility (MHC) class II molecules are transmembrane proteins with a central role in immune system regulation. The protein encoded by this gene, together with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates transcription. This complex associates with the non-DNA-binding factor MHC class II transactivator (CIITA), which determines cell type specificity and inducibility of MHC class II gene expression. The protein contains ankyrin repeats involved in protein–protein interactions. Mutations in this gene are linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described, with only one showing activation activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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