Thermo Fisher Scientific DRD2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human, mouse, and rat DRD2. Validated for WB, IHC, ICC, and ELISA. Supplied as liquid, 1 mg/mL, purified by Protein A. Suitable for research on dopamine receptor function and neurological studies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human DRD2 (amino acids 201–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 1% BSA and 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The DRD2 (Dopamine Receptor D2) is involved in neuromodulation of appetitive behaviors. It has been linked to alcoholism and other substance-use disorders. In mice, DRD2 mutations lead to suppression of reward behavior with morphine and reduced spontaneous movement, resembling Parkinson’s disease. Three alternatively spliced isoforms have been identified. DRD2 is expressed in various brain regions, as well as in aorta, artery, eye, and spinal cord. ESTs have been isolated from normal pituitary and in brain, colon, lung, pancreas, and skeletal muscle cancer libraries.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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