Thermo Fisher Scientific L1CAM Monoclonal Antibody (OTI1D12), TrueMAB
L1CAM 단백질을 타겟으로 하는 Mouse Monoclonal Antibody. Western blot, ICC/IF, Flow Cytometry에 적합. 정제된 Lyophilized 형태로 제공되며, 재구성 후 약 1 mg/mL 농도. 인간 시료에 반응하며 신경 발달 관련 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D12 |
| Immunogen | Full length human recombinant protein of human L1CAM produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin superfamily.
Its ectodomain consists of immunoglobulin-like and fibronectin type III-like domains, linked via a transmembrane region to a conserved cytoplasmic domain.
L1CAM is crucial for nervous system development, including neuronal migration and differentiation.
Mutations in this gene are associated with X-linked neurological syndromes collectively known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus).
Alternative splicing of a neuron-specific exon is functionally relevant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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