Thermo Fisher Scientific L1CAM Monoclonal Antibody (OTI1A8), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

L1CAM (CD171) is an axonal glycoprotein belonging to the immunoglobulin supergene family.
Its ectodomain contains multiple immunoglobulin-like and fibronectin type III domains linked to a conserved cytoplasmic domain.
L1CAM plays a crucial role in neuronal migration and differentiation during nervous system development.
Mutations in the L1CAM gene cause X-linked neurological syndromes collectively known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus).
Alternative splicing of a neuron-specific exon is functionally relevant.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.