Thermo Fisher Scientific ARK5 Polyclonal Antibody
ARK5(NUAK1) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 ELISA에 사용 가능. Human 및 Rat 시료에 반응하며, 액상 형태로 제공. Affinity Chromatography로 정제되어 높은 특이성과 재현성을 보장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 362–661 of human NUAK1 (NP_055655.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.4 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855458 |
Product Specific Information
Immunogen sequence:
LERQRSLKKS KKENDFAQSG QDAVPESPSK LSSKRPKGIL KKRSNSEHRS HSTGFIEGVV GPALPSTFKM EQDLCRTGVL LPSSPEAEVP GKLSPKQSAT MPKKGILKKT QQRESGYYSS PERSESSELL DSNDVMGSSI PSPSPPDPAR VTSHSLSCRR KGILKHSSKY SAGTMDPALV SPEMPTLESL SEPGVPAEGL SRSYSRPSSV ISDDSVLSSD SFDLLDLQEN RPARQRIRSC VSAENFLQIQ DFEGLQNRPR PQYLKRYRNR LADSSFSLLT DMDDVTQVYK QALEICSKLN
Target Information
NUAK1 (ARK5) is a serine/threonine kinase involved in multiple cellular processes. Overexpression is linked to tumor invasion and metastasis, particularly in colorectal neoplasms. It regulates cellular senescence and ploidy via phosphorylation of LATS1 at Ser-464, influencing its stability. NUAK1 also controls cell adhesion through modulation of myosin protein phosphatase 1 (PP1) activity by phosphorylating PPP1R12A, leading to reduced dephosphorylation of MLC2. It may participate in DNA damage response by phosphorylating p53 at Ser-15 and Ser-392 and acting in CDKN1A promoter activation. NUAK1 can promote tumor malignancy under AKT1 regulation and suppress Fas-induced apoptosis via CASP6 phosphorylation. It also contributes to UV-induced DNA damage response and CDKN1A degradation for optimal DNA repair.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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