Thermo Fisher Scientific NRXN3 Polyclonal Antibody

Thermo Fisher Scientific NRXN3 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:1,000–1:2,000
• ELISA: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
ILLYAMYKYR NRDEGSYQVD ETRNYISNSA QSNGTLMKEK QQSSKSGHKK QKNKDREYYV

Target Information

Neurexins comprise a family of neuronal cell surface proteins, including neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3), and Caspr (neurexin IV).
Neurexins I–III are expressed as α and β isoforms:

• α isoforms: Composed of three cassettes with two LNS (Laminin A, Neurexins, Sex hormone-binding) domains separated by EGF domains, followed by a transmembrane region and a cytoplasmic C-terminal of 55 amino acids. Bind to neurexophilins and α-latrotoxin.
• β isoforms: Contain one LNS-domain, bind to neuroligins, and play a role in synapse formation and remodeling.

Caspr (Contactin-Associated Protein 1, also known as Paranodin in mouse) shares structural similarity with neurexins and interacts with Contactin.
Caspr and Caspr2 demarcate distinct subdomains in myelinated axons:

• Caspr: Located at paranodal junctions.
• Caspr2: Colocalizes with Shaker-like K⁺ channels in the juxtaparanodal region.

Caspr may contribute to glial-neuronal communication during development.

Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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