Thermo Fisher Scientific POM121 Polyclonal Antibody
POM121 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 사용 가능. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. 고순도(>95%)이며 1 mg/mL 농도의 액상 형태로 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminus of human POM121 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553555 |
Product Specific Information
- Detects endogenous POM121 protein at approximately 121 kDa.
- Purity >95% by SDS-PAGE.
Target Information
POM121 (POM121 membrane glycoprotein), also known as POM121A (nuclear envelope pore membrane protein POM 121A), NUP121 (nucleoporin Nup121), or pore membrane protein of 121 kDa, is a 1,249 amino acid single-pass membrane protein that exists as three alternatively spliced isoforms and belongs to the POM121 family.
Encoded by a gene located on human chromosome 7q11.23, POM121 is highly conserved and localizes to the nuclear and endoplasmic reticulum membranes.
It is an essential component of the nuclear pore complex (NPC), required for nuclear envelope formation and NPC biogenesis.
POM121 associates with the central spoke ring complex and anchors pore complex components to the pore membrane via its F-X-F-G repeat-containing domain.
Overexpression of POM121 induces cytoplasmic annulate lamellae (AL) formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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