Thermo Fisher Scientific LC3B Polyclonal Antibody
LC3B 단백질을 인식하는 Rabbit Polyclonal Antibody로, 오토파지 관련 연구에 적합. Mouse와 Zebrafish에 반응하며, Western blot에 최적화. Protein A 및 항원 친화 크로마토그래피로 정제된 고순도 항체. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 16–50 amino acids from the N-terminal region of DANRE map1lc3b |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2900989 |
Target Information
LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3 B) in humans is encoded by the gene MAP1LC3B (Microtubule-associated proteins 1A/1B light chain 3B).
LC3B is associated with microtubule assembly and plays an important role in neurogenesis.
Studies indicate LC3B is vital in autophagy — a process involving bulk degradation of cytoplasmic components.
Three human LC3 isoforms undergo post-translational modifications during autophagy.
Macroautophagy, the major inducible pathway for cytoplasmic turnover, is responsible for degradation of active cytoplasmic enzymes and organelles during nutrient starvation.
This process involves formation of double-membrane autophagosomes that fuse with lysosomes, releasing autophagic bodies for degradation.
LC3B mediates interactions between microtubules and cytoskeletal components and may be involved in cancer, aging, metabolic, neurodegenerative, and cardiovascular/pulmonary diseases.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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