Thermo Fisher Scientific MELK Polyclonal Antibody
Thermo Fisher Scientific MELK Polyclonal Antibody는 Mouse MELK 단백질을 표적하는 Rabbit IgG 기반의 폴리클로날 항체입니다. Western blot에 적합하며, 단백질 A 및 항원 친화 크로마토그래피로 정제되었습니다. 암 관련 MELK 연구 및 세포주기 조절 분석에 유용합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 381–415 amino acids from the central region of Mouse Melk |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2900988 |
Target Information
MELK is a serine/threonine kinase related to the AMPK family, associated with cell cycle regulation. It is overexpressed in various cancers and considered a potential therapeutic target. MELK phosphorylates substrates such as BCL2L14, CDC25B, MAP3K5/ASK1, and ZNF622, playing roles in apoptosis activation, cell cycle progression, and carcinogenesis. It is essential for proliferation of embryonic and postnatal neural progenitors and may influence mammary carcinogenesis through inhibition of BCL2L14. Additionally, it contributes to spliceosome assembly inhibition during mitosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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