Thermo Fisher Scientific MAVS Polyclonal Antibody
MAVS 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat 반응성 보유하며, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human MAVS (amino acids 3–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway depends on Toll-like receptors (TLRs), while the other uses RNA helicase RIG-I to detect intracellular viral double-stranded RNA.
MAVS is a mitochondrial membrane protein essential for IFN-β signaling, recruiting IRF-3 to RIG-I and activating NF-κB. It interacts with innate immune components such as TRIF, TRAF2, TRAF6, and kinases IKK-α, IKK-β, and IKK-ι.
Cleavage of MAVS by Hepatitis C virus protease allows viral immune evasion. Multiple MAVS isoforms are known.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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