Thermo Fisher Scientific BCL-10 Polyclonal Antibody
BCL-10 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(P) 실험에 적합. Human, Mouse, Rat 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. 세포질 및 막 주변에서 발현되는 BCL-10 검출에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide of internal segment of human BCL-10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human hepatocellular and lung carcinoma tissues
- Cellular location: Cytoplasm, perinuclear region, membrane
Target Information
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 also acts as an adapter protein linking the upstream TNFR1-TRADD-RIP complex with the downstream NIK-IKK-IKAP complex. It serves as a substrate for MALT1. Mutations in the BCL-10 gene can lead to Immunodeficiency 37 or mucosa-associated lymphoid type lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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