Thermo Fisher Scientific TAB3 Polyclonal Antibody
Rabbit 유래의 Polyclonal 항체로, TAB3 단백질을 표적합니다. Western blot 및 Immunoprecipitation에 사용 가능하며, NF-kappaB 신호전달 및 자가포식 연구에 적합합니다. 1 mg/mL 농도의 액상 형태로 4°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 600 and 650 of Human TAK1 binding protein 3 (mitogen-activated protein kinase kinase kinase 7 interacting protein 3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2 form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor.
Recent experiments have shown that TAB2 and the related protein TAB3 constitutively interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibits autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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