Thermo Fisher Scientific CDKL5 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CDKL5 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CDKL5,uniProtId:O76039-2,ncbiNodeId:9606,antigenRange:636-758,antigenLength:960,antigenImageFileName:PA5-51752_CDKL5_O76039-2_Rabbit.svg,antigenImageFileNamePDP:PA5-51752_CDKL5_O76039-2_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.20 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2639615

Product Specific Information

Immunogen sequence: AARANSLQLL SPQPGEQLPP EMTVARSSVK ETSREGTSSF HTRQKSEGGV YHDPHSDDGT APKENRHLYN DPVPRRVGSF YRVPSPRPDN SFHENNVSTR VSSLPSESSS GTNHSKRQPA FDP

Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 97%.

Target Information

CDKL5 serine/threonine kinase (STK9) is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome and Rett syndrome (RTT). CDKL5 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing by controlling splicing factor dynamics. The mutations in CDKL5 are major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.