Thermo Fisher Scientific SLC15A1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
DKTLPVFPKG NEVQIKVLNI GNNTMNISLP GEMVTLGPMS QTNAFMTFDV NKLTRINISS PGSPVTAVTD DFKQGQRHTL LVWAPNHYQV VKDGLNQKPE KGENGIRFVN TFNELITITM SGKVYANISS YNA

• Highest antigen sequence identity to the following orthologs:
  • Mouse: 74%
  • Rat: 72%

Target Information

In mammalian small intestine, the proton-coupled peptide transporter (PEPT) is responsible for the absorption of small peptides arising from digestion of dietary proteins. PEPT1, a hydrogen ion/peptide cotransporter, transports dipeptides and tripeptides, but not free amino acids or peptides with more than three amino acid residues. Its driving force for uphill transport requires proton binding and the presence of an inside-negative membrane potential.

PEPT1 is a 708 amino acid protein containing 12 putative membrane-spanning domains and is expressed in Caco-2 cells. It plays important roles in nutritional and pharmacological therapies. The mammalian kidney expresses a proton-coupled peptide transporter, PEPT2, responsible for absorption of small peptides, beta-lactam antibiotics, and other peptide-like drugs from the tubular filtrate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.