Thermo Fisher Scientific NEDD9 Monoclonal Antibody (1B4)
인간 NEDD9 단백질을 인식하는 Mouse IgG1 단클론 항체. Western blot과 ELISA에 최적화된 시약으로 세포 신호전달 및 암 연구에 활용 가능. 액상 형태, 방부제 무첨가, -20°C 보관.
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Thermo Fisher Scientific NEDD9 Monoclonal Antibody (1B4)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B4 |
| Immunogen | NEDD9 (NP_006394, 101–200 a.a.) partial recombinant protein with GST tag. MW of GST tag alone: 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
PRDTIYQVPP SYQNQGIYQV PTGHGTQEQE VYQVPPSVQR SIGGTSGPHV GKKVITPVRT GHGYVYEYPS RYQKDVYDIP PSHTTQGVYD IPPSSAKGPV
Target Information
HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis, and oncogenic transformation. The Cas family of docking proteins are substrates of focal adhesion kinase (FAK) and Src family tyrosine kinases, both active targets for drug development. HEF1 protein production increases mRNA levels for motility and transformation-related proteins, including metalloproteinases, MLCK, p160ROCK, and ErbBi. Overproduction mediates apoptosis in epithelial-derived cell lines such as MCF7 and HeLa. Overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance, emphasizing the importance of studying this protein family in cancer prognosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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