Thermo Fisher Scientific CD206 Polyclonal Antibody
CD206(MRC1) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 Affinity 정제 및 안정적 PBS/glycerol buffer 제공. 연구용 한정.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | 5 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Fungi, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MRC1 (Accession P22897), corresponding to amino acid residues P642–N692 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851091 |
Product Specific Information
Antibody detects endogenous levels of total MRC1.
Target Information
CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. It is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells, and sperm cells. CD206 plays roles in innate and adaptive immune responses and mediates recognition and uptake of various macromolecules, including modified lipoproteins, advanced glycation end products (AGEs), and amyloid β-protein (Aβ).
CD206 is implicated in atherosclerosis and amyloid β deposition in Alzheimer’s disease (AD). The CD206 gene encodes class A macrophage scavenger receptors with three isoforms (1, 2, 3) generated by alternative splicing. Isoforms 1 and 2 are functional receptors mediating endocytosis of modified LDL, while isoform 3 is non-functional and can inhibit the activity of isoforms 1 and 2, suggesting a regulatory mechanism in macrophages.
Diseases associated with CD206 dysfunction include leprosy and Gaucher’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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