Thermo Fisher Scientific Chk1 Monoclonal Antibody (AF7F4)
Chk1 단백질을 인식하는 AF7F4 클론의 mouse monoclonal antibody. Western blot과 immunoprecipitation에 사용 가능. DNA 손상 반응 및 세포주기 연구에 적합. 액상 형태로 제공되며 -20°C에서 보관.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunoprecipitation (IP) | 1–2 µL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AF7F4 |
| Immunogen | Recombinant human protein purified from E. coli (His-CHK1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2538705 |
Product Specific Information
A suggested positive control for this product is RD cells.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. It acts as a key mediator in the DNA damage-induced checkpoint network and is evolutionarily conserved to maintain genomic stability under genotoxic stress. Inhibition of CHK1 can induce mitotic catastrophe and apoptosis in p53-deficient cancer cells, making CHK1 a promising therapeutic target for cancer treatment, particularly in tumors lacking p53 function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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