Thermo Fisher Scientific Chk1 Monoclonal Antibody (AF7F4)
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
MA517237 | - | Thermo Fisher Scientific MA517237 Chk1 Monoclonal Antibody (AF7F4) 100 ul pk | 재고문의 | pk | 0원 | - | 0원 |
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Applications
Tested Dilution
Publications
Western Blot (WB)
1:1,000
Immunoprecipitation (IP)
1-2 µL
Product Specifications
Host/Isotype
Mouse / IgG1
Class
Monoclonal
Type
Antibody
Clone
AF7F4
Immunogen
Recombinant human protein purified from E.coli (His-CHK1)
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
2 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2538705
Product Specific Information
A suggested positive control for this product is RD cells.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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