Thermo Fisher Scientific DUSP12 Monoclonal Antibody (AF28B2)
DUSP12 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체. Western blot과 ELISA에 적합하며, 비결합형 액상 형태로 제공. 세포 내 MAPK 신호 조절 연구에 유용. -20°C에서 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AF28B2 |
| Immunogen | Recombinant human protein purified from E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2538709 |
Product Specific Information
A suggested positive control for this product is Bosc23 cell lysate transfected with Myc/His/DUSP12.
Target Information
Dual specificity phosphatases (DUSPs) inactivate their target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues. DUSPs are categorized into six subgroups based on sequence similarity: PRLs, Cdc14 phosphatases, PTENs, myotubularins, MKPs, and atypical DUSPs.
DUSP inhibitors can modulate MAPK and cellular responses in both positive and negative ways. The expression and activity of DUSP family members across cells and tissues regulate MAPK signaling intensity and duration, influencing physiological outcomes.
DUSP12 (YVH1, GKAP) contains a conserved DUSP catalytic domain and an extended C-terminal domain of unknown function, possibly related to glucokinase regulation. It is localized in the cytoplasm and nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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