Thermo Fisher Scientific FIG4 Polyclonal Antibody
Rabbit polyclonal antibody targeting FIG4 protein, suitable for WB, IHC, and ICC applications. Recombinant antigen fragment (aa 135–430). High predicted reactivity across multiple species. Provided as unconjugated liquid form, 1 mg/mL concentration, st...
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 135–430 of FIG4 (Uniprot ID# Q92562) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11154122 |
Product Specific Information
- Recommended positive controls: HeLa, HCT116
- Predicted reactivity: Mouse (95%), Rat (93%), Dog (98%), Pig (97%), Chicken (90%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain (~400 amino acids) consists of seven conserved motifs and exhibits phosphoinositide phosphatase activity. The yeast homolog Sac1p regulates various phosphoinositides, impacting cellular functions such as actin cytoskeleton organization, Golgi function, and vacuole morphology. Membrane-bound phosphoinositides act as signaling molecules and are crucial for vesicle trafficking in eukaryotic cells. Mutations in this gene are associated with Charcot-Marie-Tooth disease, type 4J.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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