Thermo Fisher Scientific INSR alpha Chimeric Recombinant Rabbit Monoclonal Antibody (83-7)
INSR alpha의 세포외 도메인을 인식하는 재조합 토끼 단클론 항체. IHC, Flow Cytometry, ELISA, IP 등 다양한 응용 가능. 높은 특이성과 재현성을 제공하며, Protein A로 정제된 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Flow Cytometry (Flow) | 10 µg/mL |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 83-7 |
| Immunogen | Epitope within amino acids 140–301 (cysteine-rich region) of the extracellular domain of human Insulin Receptor alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074241 |
Product Specific Information
Specificity: Recognises the extracellular domain of the Insulin Receptor alpha.
Target Information
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of phosphorylation cascades. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These receptors differ in sequence in regions conferring ligand specificity and intracellular signaling domains, resulting in distinct functional outcomes. Defects in the insulin receptor are associated with insulin resistance syndromes, while IGF-1R defects may cause growth retardation. Both signaling cascades are implicated in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: MA5-47793_INSR_alpha_P06213-1_Rabbit.svg)
(이미지: MA5-47793_INSR_alpha_P06213-1_Rabbit_PDP.jpeg)
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