Thermo Fisher Scientific INSR alpha Recombinant Mouse Monoclonal Antibody (83-7)
인슐린 수용체 알파의 세포외 도메인을 인식하는 재조합 마우스 단클론 항체입니다. IHC, ELISA, IP 등 다양한 분석에 사용 가능하며, HEK293 세포에서 발현된 IgG1 카파 형태입니다. 단백질 A로 정제되어 1 mg/mL 농도로 제공되며, 연구용으로만 사용됩니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
- ELISA: Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 83-7 |
| Immunogen | Epitope within amino acids 140–301 (the cysteine-rich region) of the extracellular domain of the human Insulin Receptor alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074240 |
Product Specific Information
Specificity: Recognises the extracellular domain of the Insulin Receptor alpha.
Target Information
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of phosphorylation cascades.
Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins.
These receptors differ in sequence in regions that confer ligand specificity and intracellular signaling domains, resulting in distinct functional outcomes.
Defects in the insulin receptor (IR) are associated with insulin resistance syndromes, while IGF-1R defects may cause growth retardation. Both signaling cascades are also implicated in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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