Thermo Fisher Scientific Catenin alpha-1 Monoclonal Antibody (8B6C1)
Catenin alpha-1 단백질을 인식하는 mouse monoclonal 항체로, Western blot, IHC, ELISA에 적합합니다. 고순도 Protein G 정제 항체이며, PBS 버퍼에 0.05% sodium azide가 포함되어 있습니다. 세포 접착 및 cadherin 복합체 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8B6C1 |
| Immunogen | Purified recombinant fragment of human CTNNA1 (aa 371–574) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898418 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
Catenin alpha-1 associates with the cytoplasmic domain of various cadherins. These catenin-cadherin complexes connect to the actin filament network, playing a key role in cell adhesion. It can associate with both E- and N-cadherins. While initially thought to mediate direct linkage to actin, later studies suggest CTNNA1 does not bind F-actin in the complex, indicating a different linkage mechanism. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex, thus contributing to cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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