Thermo Fisher Scientific MEPCE Monoclonal Antibody (OTI2E7)
MEPCE 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (OTI2E7). Western blot 검증 완료. Human 및 Mouse 반응성. Lyophilized 형태, 1 mg/mL 농도, PBS + 8% trehalose buffer. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:250–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E7 |
| Immunogen | Human recombinant protein fragment (aa 1–289 of human MEPCE, NP_062552) produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
MEPCE is an S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5′ end of 7SK snRNA, stabilizing it.
It also functions non-enzymatically as part of the 7SK RNP complex, which regulates transcription elongation by sequestering P-TEFb and promoting snRNA gene transcription via interaction with the little elongation complex (LEC).
Within the 7SK RNP complex, MEPCE stabilizes 7SK RNA and facilitates complex assembly through interaction with LARP7, occluding its catalytic center.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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