Thermo Fisher Scientific GABRA6 Polyclonal Antibody
Thermo Fisher Scientific의 GABRA6 Polyclonal Antibody는 Mouse와 Rat 시료에 반응하는 Rabbit IgG 기반 항체로, Western blot에 적합합니다. GABA-A receptor의 alpha 6 subunit을 인식하며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA595656
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein from the cytoplasmic loop of the alpha 6 subunit |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.15 mg/mL |
| Purification | Antigen Affinity Chromatography |
| Storage Buffer | 10 mM HEPES, pH 7.5, with 100 µg/mL BSA, 50% glycerol, 150 mM NaCl |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2807458 |
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization of the membrane through the opening of a Cl⁻ channel associated with the GABA-A receptor (GABA-A R) subtype.
GABA-A receptors are important therapeutic targets for sedative, anxiolytic, and hypnotic agents and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.
The GABA-A receptor is a multimeric subunit complex consisting of six alpha, four beta, and four gamma subunits, including splice variants. Expression studies show that both alpha and beta subunits form functional GABA-A receptors sensitive to GABA, while coexpression with a gamma subunit is required for benzodiazepine modulation.
Different alpha subunits may mediate distinct benzodiazepine effects in the brain, and phosphorylation of beta subunits modulates receptor function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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