Thermo Fisher Scientific Fractin Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Immunohistochemistry (IHC)

1:100

-

Immunocytochemistry (ICC/IF)

1:100-1:500

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acid residues from the C terminal region of the 32-kDa actin fragment

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807454

Product Specific Information

This antibody is specific for endogenous levels of the ~32 kDa fractin protein and shows no reactivity toward intact actin. There is often a ladder of smaller bands in cells or culture or in-vivo preparations due to further degradation by other proteases. In IHC, the antibody detects the processes and cell bodies of degenerating neurons and plaque-associated microglia in Alzheimer`s disease.

Target Information

Fractin (fragment of actin) is a caspase-specific cleavage product of actin and serves as a novel marker of apoptosis-related events. It has recently been reported that fractin may have a functional role in apoptotic signaling in oligodendrocytes (Schulz, R., et al., Glia, 2009).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.