Thermo Fisher Scientific MAPKBP1 Polyclonal Antibody
MAPKBP1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 검증됨. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체. 세포 신호전달 연구용으로 적합.
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- PA576477
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC(P)) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide of human MAPKBP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.2) with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720204 |
Product Specific Information
This antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
MAP kinases are involved in key biological processes such as cell adhesion, spreading, differentiation, and apoptosis.
MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1,514 amino acid protein containing twelve WD repeats.
It is induced by TRAF2 and Tak1 and functions as an adaptor protein for NF-κB activation.
MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination.
The protein exists as six alternatively spliced variants and is encoded on human chromosome 15, which carries over 700 genes and represents about 3% of the human genome.
Defects in chromosome 15 genes are associated with Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease, and Marfan syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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