Thermo Fisher Scientific Nitrotyrosine Polyclonal Antibody, HRP
Nitrotyrosine 검출용 HRP 결합 폴리클로날 항체로, Western blot 및 ELISA에 사용 가능. Goat IgG 기반 항체이며 항원 친화 크로마토그래피로 정제됨. 세포 손상 및 염증, NO 생성 관련 연구에 적합. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Nitrotyrosine Polyclonal Antibody, HRP
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:8,000 |
| ELISA | 1:1,000–1:8,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chemical |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | NY-KLH |
| Conjugate | HRP |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.01% thimerosal |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Nitrotyrosine is a relatively stable product formed through several reaction pathways, most notably the reaction of peroxynitrite (from superoxide and nitric oxide radicals) with tyrosine. As a strong oxidant and nitrating agent, peroxynitrite mediates tyrosine nitration reactions on proteins, leading to inactivation of enzymes such as alpha1-antiproteinase, catalase, and superoxide dismutase (SOD).
Nitrotyrosine serves as an indicator of cell damage, inflammation, and nitric oxide production. Measuring nitrotyrosine concentration can help assess NO-induced cellular damage. It has been implicated in multiple human diseases including Alzheimer’s, Parkinson’s, multiple sclerosis, ALS, asthma, atherosclerosis, and other conditions related to endothelial injury. Tyrosine nitration may alter protein function, as demonstrated for p53 and MnSOD.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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