Thermo Fisher Scientific Phospho-PDGFRB (Tyr740) Recombinant Rabbit Monoclonal Antibody (SN0646)
PDGFRB Tyr740 인산화 부위를 인식하는 재조합 토끼 단클론 항체. Western blot 및 면역형광에 최적화. 인간 및 랫트 반응성. Protein A 정제, 1 mg/mL 액상 형태. 단기 4℃, 장기 -20℃ 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN0646 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Tyr740 of human PDGFR beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2911581 |
Product Specific Information
- Positive Control: C2C12, HeLa, L6
- Subcellular Location: Cell membrane, Cytoplasmic vesicle
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the receptor is a homodimer or heterodimer composed of both PDGFR alpha and beta polypeptides. The gene is located on chromosome 5, near the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, which may be involved in the 5-q syndrome. A translocation between chromosomes 5 and 12, fusing PDGFRB (CD140b) with ETV6, results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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