Thermo Fisher Scientific PYK2 Recombinant Rabbit Monoclonal Antibody (SC06-15)
PYK2 단백질을 표적하는 재조합 토끼 단클론 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 단백질 A로 정제된 액상 항체로 안정적이며, 세포막 및 세포골격 관련 연구에 적합.
- 카탈로그번호
- MA542439
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SC06-15 |
| Immunogen | Synthetic peptide within N-terminal human PYK2 (UniProt ID: Q14289-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2911580 |
Product Specific Information
Positive Control:
Mouse brain tissue lysates, Hela, SHG-44, SH-SY5Y, human tonsil tissue, human spleen tissue, human kidney tissue, mouse brain tissue, mouse kidney tissue.
Subcellular Location:
Cell membrane, nucleus, cytoplasm, perinuclear region, focal adhesion, lamellipodium, cell cortex.
Target Information
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. It regulates actin cytoskeleton reorganization, cell polarization, migration, adhesion, spreading, and bone remodeling. FAK2 also plays a role in humoral immune response regulation and is required for normal levels and migration of splenic B-cells. It functions downstream of integrin, collagen, immune, G-protein coupled, cytokine, chemokine, and growth factor receptors, mediating responses to cellular stress. Aberrant expression may contribute to cancer cell proliferation, migration, and invasion. Elevated expression has been observed in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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