Thermo Fisher Scientific WRN Polyclonal Antibody
WRN 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 적합. Human 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 액상 형태로 4°C 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- A300238A
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:5,000–1:25,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 400–450 of Human Werner Syndrome Helicase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
This gene encodes a member of the RecQ subfamily and the DEAH subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair.
This protein contains a nuclear localization signal in the C-terminus and shows predominant nucleolar localization. It possesses intrinsic 3′ to 5′ DNA helicase activity and also a 3′ to 5′ exonuclease function.
Based on interactions between this protein and the Ku70/80 heterodimer in DNA end processing, it may be involved in the repair of double-strand DNA breaks.
Defects in this gene cause Werner syndrome, an autosomal recessive disorder characterized by premature aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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