Thermo Fisher Scientific LAT Monoclonal Antibody (LAT-01)
LAT 단백질을 인식하는 인간 반응성 마우스 단클론 항체로, Western blot, Flow cytometry, Immunoprecipitation에 사용 가능. 비결합형 액상 형태로 4°C 보관. T세포 활성화 및 신호전달 연구에 적합.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | |
| Flow Cytometry (Flow) | 1–4 µg/mL | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LAT-01 |
| Immunogen | Bacterially produced recombinant polypeptide corresponding to the entire cytoplasmic domain of human LAT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076434 |
Product Specific Information
This antibody reacts with an intracellular epitope of LAT, a 36–38 kDa transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells, and platelets.
This antibody does not cross-react with mouse.
Target Information
LAT (Linker for Activation of T cells) is a 36–38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells, and platelets.
After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules.
LAT is essential for TCR-dependent T cell and FcεRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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