Thermo Fisher Scientific c-Abl Polyclonal Antibody
Rabbit polyclonal antibody targeting human c-Abl (ABL1) for WB and IHC applications. Recognizes C-terminal region (aa 851–881). Purified by Protein A and antigen affinity chromatography. Supplied in PBS with sodium azide; store at 4°C or −20°C.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 851–881 of the C-terminal region of human c-Abl (ABL1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A and antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C for short term; for long term, store at −20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2257733 |
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response. Its activity is negatively regulated by the SH3 domain; deletion of this domain converts c-Abl into an oncogene. The DNA-binding activity of ABL1 is regulated by CDC2-mediated phosphorylation, indicating a role in the cell cycle.
In chronic myelogenous leukemia (CML) and some acute lymphoblastic leukemias (ALL), c-Abl undergoes a (9;22) chromosomal translocation forming the Philadelphia chromosome, which fuses c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-Abl may also regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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