Thermo Fisher Scientific c-Abl Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

This antibody is predicted to react with mouse based on sequence homology.

Target Information

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
c-Abl activity is negatively regulated by its SH3 domain, and deletion of this domain converts c-Abl into an oncogene.
Its DNA-binding activity is controlled by CDC2-mediated phosphorylation, implying a role in the cell cycle.
In chronic myelogenous leukemia and certain acute lymphoblastic leukemias, the c-Abl gene undergoes a (9;22) translocation, forming the Philadelphia chromosome and fusing with the Bcr gene.
The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV).
c-Abl may regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.