Thermo Fisher Scientific ATP1B1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Predicted to react with bovine, canine, human, and porcine based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

The protein encoded by this gene belongs to the family of Na⁺/K⁺ and H⁺/K⁺ ATPases beta chain proteins, and to the subfamily of Na⁺/K⁺-ATPases.
Na⁺/K⁺-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, sodium-coupled transport of various molecules, and electrical excitability of nerve and muscle cells.
This enzyme is composed of two subunits: a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates the number of sodium pumps transported to the plasma membrane via alpha/beta heterodimer assembly. The glycoprotein subunit of Na⁺/K⁺-ATPase is encoded by multiple genes, and this gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, though their biological validity is not confirmed.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.