Thermo Fisher Scientific Connexin 43 Polyclonal Antibody
Rat 유래 Connexin 43 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며, 다양한 종에서 높은 상동성 예측. Affinity chromatography로 정제된 액상 형태로 제공. -20°C에서 보관, 방부제 무첨가.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal region of rat GJA1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2110189 |
Product Specific Information
- Predicted to react with chicken, canine, finch, human, mouse, non-human primate, sheep, Xenopus, and zebrafish based on 100% sequence homology.
- Specific for ~43 kDa Connexin43 protein.
- Immunohistochemistry not recommended.
Target Information
Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as hexamers and are transported to the plasma membrane to form hemichannels that connect adjacent cells, creating intercellular channels known as gap junctions. These structures are essential for cell-to-cell communication, development, and growth regulation.
Phosphorylation of Cx43 regulates gap junction assembly and function. Protein kinase C (PKC) phosphorylates Ser368, reducing intercellular communication, while Src kinase also modulates Cx43 phosphorylation. Connexin 43 is the major gap junction protein in the heart, crucial for synchronized cardiac contraction and embryonic development. Mutations in related genes can cause various inherited disorders, including Charcot-Marie-Tooth disease and heart malformations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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