Thermo Fisher Scientific Bcl-X Polyclonal Antibody
Bcl-X 단백질을 인식하는 Rabbit Polyclonal 항체로 Western Blot에 최적화됨. Human, Dog, Cat, Sheep 시료에 반응. 항원 친화 크로마토그래피로 정제된 액상 제품이며, 4°C 보관. 연구용으로 세포사멸 관련 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Cat, Human, Sheep |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide made to an N-terminal portion of human BCL2L1 (within residues 30–70). [Swiss-Prot# Q07817] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_1956299 |
Product Specific Information
- The target sequence has 93% sequence homology with porcine, 87% with mouse, and 81% with rat.
- This antibody is not recommended for ICC/IF applications.
Target Information
The protein encoded by the BCL-X (BCL2L1) gene belongs to the BCL-2 protein family.
Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities.
These proteins are located at the outer mitochondrial membrane and regulate the VDAC channel opening, which controls mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release — key factors in apoptosis induction.
Alternative splicing produces multiple transcript variants encoding two isoforms:
- The longer isoform acts as an apoptotic inhibitor.
- The shorter isoform acts as an apoptotic activator.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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