Thermo Fisher Scientific GABRA1 Polyclonal Antibody
GABRA1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 적합합니다. Mouse와 Rat에 반응하며, 비인간 영장류 및 인간에도 예측 반응합니다. 친화 크로마토그래피로 정제되었고, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1:100 | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein from the cytoplasmic loop of the alpha 1 subunit of rat GABRA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | ~0.15 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_559218 |
Product Specific Information
This antibody is predicted to react with bovine, canine, human, and non-human primate based on 100% sequence homology.
It is specific for the ~51 kDa alpha1-subunit of the GABAA Receptor in Western blots of rat brain.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization of the membrane through the opening of a Cl⁻ channel associated with the GABAA receptor (GABAA-R) subtype.
GABAA-Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.
The GABAA-R is a multimeric subunit complex consisting of six alpha, four beta, and four gamma subunits, including splice variants. Expression of alpha- and beta-subunits results in functional GABAA-R sensitive to GABA, while coexpression of gamma-subunits is required for benzodiazepine modulation.
Different alpha-subunits mediate varying benzodiazepine effects, and phosphorylation of beta-subunits modulates receptor function.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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