Thermo Fisher Scientific Phospho-ErbB3 (Tyr1289) Polyclonal Antibody
ERBB3의 Tyr1289 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 1 mg/mL 농도, PBS + 50% glycerol에 보관. -20°C에서 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ERBB3 (Accession P21860), corresponding to amino acid residues around phosphorylated Tyr1289 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815941 |
Product Specific Information
This antibody detects endogenous levels of ERBB3 only when phosphorylated at Tyr1289.
Target Information
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is overexpressed in various tumors such as prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6.2 kb mRNA, translated into a 160/180 kDa glycoprotein. It encodes a transmembrane receptor tyrosine kinase that can form heterodimers with other EGF receptor family members, leading to activation of pathways involved in cell proliferation or differentiation.
Alternative splicing produces different isoforms, including a secreted form that modulates the activity of the membrane-bound receptor. Additional splice variants have been reported but are not fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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