Thermo Fisher Scientific ASGR1 Polyclonal Antibody
ASGR1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, ELISA에 적합하며 Human, Mouse, Rat 반응성. 고순도 Affinity Chromatography 정제, -20°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 62–291 of human ASGR1 (NP_0016621) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.38 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805375 |
Product Specific Information
Positive Samples: HepG2, 22Rv1, SW620, Mouse liver, Mouse lung, Mouse testis, Rat liver, Rat lung, Rat testis
Cellular Location: Membrane, Single-pass type II membrane protein
Immunogen Sequence:
QNSQLQEELR GLRETFSNFT ASTEAQVKGL STQGGNVGRK MKSLESQLEK QQKDLSEDHS SLLLHVKQFV SDLRSLSCQM AALQGNGSER TCCPVNWVEH ERSCYWFSRS GKAWADADNY CRLEDAHLVV VTSWEEQKFV QHHIGPVNTW MGLHDQNGPW KWVDGTDYET GFKNWRPEQP DDWYGHGLGG GEDCAHFTDD GRWNDDVCQR PYRWVCETEL DKASQEPPLL
Target Information
The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) that mediates binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues. It is expressed on hepatocyte surfaces in a polar manner—present on sinusoidal and lateral plasma membranes but absent on bile canalicular membranes.
Mammalian hepatic ASGPR mediates endocytosis and degradation of serum proteins lacking terminal sialic residues. The rat ASGPR consists of three subunits: RHL-1, RHL-2, and RHL-3. Monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 and is cross-reactive with human ASGPR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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