Thermo Fisher Scientific ASGR1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 62-291 of human ASGR1 (NP_0016621) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ASGR1,uniProtId:P07306-1,ncbiNodeId:9606,antigenRange:62-291,antigenLength:291,antigenImageFileName:PA5-89131_ASGR1_P07306-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89131_ASGR1_P07306-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.38 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805375

Product Specific Information

Positive Samples: HepG2, 22Rv1, SW620, Mouse liver, Mouse lung, Mouse testis, Rat liver, Rat lung, Rat testis; Cellular Location: Membrane, Single-pass type II membrane protein

Immunogen sequence: QNSQLQEELR GLRETFSNFT ASTEAQVKGL STQGGNVGRK MKSLESQLEK QQKDLSEDHS SLLLHVKQFV SDLRSLSCQM AALQGNGSER TCCPVNWVEH ERSCYWFSRS GKAWADADNY CRLEDAHLVV VTSWEEQKFV QHHIGPVNTW MGLHDQNGPW KWVDGTDYET GFKNWRPEQP DDWYGHGLGG GEDCAHFTDD GRWNDDVCQR PYRWVCETEL DKASQEPPLL

Target Information

The asialoglycooprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) which mediates binding, internalization and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner, i. e. it is present on the sinusoidal and lateral plasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediate the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed. The rat asialoglycoprotein receptor (ASGPR) consists of three polypeptide subunits: rat hepatic lectin (RHL)-1, RHL-2 and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.