
Thermo Fisher Scientific CD68 Polyclonal Antibody
CD68 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인체 및 마우스 시료에 반응. WB, IHC, ICC, ELISA 등 다양한 응용 가능. 고순도 Affinity Chromatography 정제, 안정적 PBS/glycerol 저장 buffer 구성. 연구용 전용 시약.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | - |
| Immunohistochemistry (IHC) | - | 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (aa 22–319 of human CD68, NP_0012422) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.91 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805377 |
Product Specific Information
- Positive Samples: Mouse fat, Mouse skin, Rat skin
- Cellular Location: Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein
- Immunogen Sequence:
NDCPHKKSAT LLPSFTVTPT VTESTGTTSH RTTKSHKTTT HRTTTTGTTS HGPTTATHNP TTTSHGNVTV HPTSNSTATS QGPSTATHSP ATTSHGNATV HPTSNSTATS PGFTSSAHPE PPPPSPSPSP TSKETIGDYT WTNGSQPCVH LQAQIQIRVM YTTQGGGEAW GISVLNPNKT KVQGSCEGAH PHLLLSFPYG HLSFGFMQDL QQKVVYLSYM AVEYNVSFPH AAQWTFSAQN ASLRDLQAPL GQSFSCSNSS IILSPAVHLD LLSLRLQAAQ LPHTGVFGQS FSCPSDRS
Target Information
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on intracellular lysosomes of monocytes and macrophages, and to a lesser extent by dendritic cells and peripheral blood granulocytes. It may play roles in phagocytic activities, lysosomal metabolism, and cell-pathogen interactions.
CD68 expression is noted in interdigitating reticulum cells, certain histiocytic lymphomas, AML, and granulocytic sarcoma. Elevated CD68 levels have been observed in CD34+ cells across various human malignancies, including Acute Myeloid Leukemia studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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