Thermo Fisher Scientific SIAH2 Polyclonal Antibody
SIAH2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등에 사용 가능. 인간 및 생쥐 반응성. 고순도 Affinity chromatography 정제, 1 mg/mL 농도, 연구용 전용.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SIAH2 Polyclonal Antibody
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SIAH2 (Accession O43255), corresponding to amino acid residues F246–C296 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852288 |
Product Specific Information
Antibody detects endogenous levels of total SIAH2.
Target Information
SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates.
SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina gene, which is essential for the development of the Drosophila R7 photoreceptor.
SIAH-2 targets TRAF2 for degradation under stress conditions such as hypoxia and also targets HIF-1 alpha prolyl hydroxylase 3 (PHD3) upon exposure to hypoxic conditions, coinciding with increased SIAH-2 transcription.
It can decrease TNF-alpha-dependent induction of JNK activity and transcriptional activation of NFkB.
SIAH-2 knockout mice subjected to hypoxia display impaired respiratory response and reduced hemoglobin levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.