Thermo Fisher Scientific SIAH2 Polyclonal Antibody
SIAH2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등에 사용 가능. 인간 및 생쥐 반응성. 고순도 Affinity chromatography 정제, 1 mg/mL 농도, 연구용 전용.
- 카탈로그번호
- PA5102907
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SIAH2 (Accession O43255), corresponding to amino acid residues F246–C296 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852288 |
Product Specific Information
Antibody detects endogenous levels of total SIAH2.
Target Information
SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates.
SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina gene, which is essential for the development of the Drosophila R7 photoreceptor.
SIAH-2 targets TRAF2 for degradation under stress conditions such as hypoxia and also targets HIF-1 alpha prolyl hydroxylase 3 (PHD3) upon exposure to hypoxic conditions, coinciding with increased SIAH-2 transcription.
It can decrease TNF-alpha-dependent induction of JNK activity and transcriptional activation of NFkB.
SIAH-2 knockout mice subjected to hypoxia display impaired respiratory response and reduced hemoglobin levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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