Thermo Fisher Scientific CD21 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total CR2/CD21.

Target Information

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, particularly breakdown fragments covalently attached to complement-activating surfaces or antigens.
It plays a crucial role in:

• Uptake and retention of immunocomplexes
• Survival of memory B cells
• Development and maintenance of humoral immune responses to T-dependent antigens

CD21 serves as a key receptor for Epstein-Barr virus (EBV) binding and is involved in targeting prions to follicular dendritic cells, facilitating neuroinvasion after peripheral exposure.
A soluble form (sCD21) is shed from the lymphocyte surface and retains ligand-binding ability.
CD21 functions as a receptor for C3d, C3dg, iC3b complement components, EBV, and IFNα.
It binds to CD23 and associates with CD19, CD81, and Leu13 to form a large signal-transduction complex involved in B cell activation.
Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9).
Alternatively spliced transcript variants encoding different CD21 isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.