Thermo Fisher Scientific CD21 Polyclonal Antibody
CD21 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 및 설치류 등 다양한 종에 반응합니다. WB 및 ICC/IF에 사용 가능하며, 친화 크로마토그래피로 정제된 액상 형태입니다. CR2 유래 펩타이드를 면역원으로 사용하며, 연구용으로 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Non-human primate, Rat, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CR2 (Accession P20023), corresponding to amino acid residues S504–Y554 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852289 |
Product Specific Information
This antibody detects endogenous levels of total CR2/CD21.
Target Information
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, particularly breakdown fragments covalently attached to complement-activating surfaces or antigens.
It plays a crucial role in:
- Uptake and retention of immunocomplexes
- Survival of memory B cells
- Development and maintenance of humoral immune responses to T-dependent antigens
CD21 serves as a key receptor for Epstein-Barr virus (EBV) binding and is involved in targeting prions to follicular dendritic cells, facilitating neuroinvasion after peripheral exposure.
A soluble form (sCD21) is shed from the lymphocyte surface and retains ligand-binding ability.
CD21 functions as a receptor for C3d, C3dg, iC3b complement components, EBV, and IFNα.
It binds to CD23 and associates with CD19, CD81, and Leu13 to form a large signal-transduction complex involved in B cell activation.
Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9).
Alternatively spliced transcript variants encoding different CD21 isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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